College Scholarships PhD in University of Heidelberg University, Germany

September 26th, 2010 by college Scholarships | Posted under College Scholarships.

PhD College Scholarships The Role of the Ubiquitin-Proteasome System in the Hypertrophic Heart, Germany

College Scholarships Description:The relationship of proteasome regulation and pathogenesis will be studied in a murine model of cardiac hypertrophy. In this exciting study with potential impact on human health, murine models of heart diseases will be utilized and monitored using in vivo measurements, such as echocardiography. The successful applicant will become proficient in a wide spectrum of current technologies in genomics, proteomics and physiology to complete the project. A strong interest in molecular pathways involved in human heart diseases and protein degradation will be highly beneficial for this project.

College Scholarships References:
1. Gomes AV, Young GW, Wang Y, Zong C, Eghbali M, Drews O, Lu H, Stefani E, Ping P. Contrasting Proteome Biology and Functional Heterogeneity of the 20S Proteasome Complexes in Mammalian Tissues. Mol Cell Proteomics. 2009 Feb; 8(2):302-15.
2. Lu H, Zong C, Wang Y, Young GW, Deng N, Souda P, Li X, Whitelegge J, Drews O, Yang PY, Ping P. Revealing the dynamics of 20S proteasome phosphoproteome: A combined CID and ETD approach. Mol Cell Proteomics. 2008 Nov; 7(11):2073-89.
3. Drews O, Wildgruber R, Zong C, Sukop U, Nissum M, Gomes AV, Ping P: Mammalian Proteasome Subpopulations with Distinct Molecular Compositions and Proteolytic Activities. Mol Cell Proteomics. 2007 Nov; 6(11): 2021-31.
4. Drews O, Zong C, Ping P: Exploring proteasome complexes by proteomic approaches. Proteomics. 2007 Apr; 7(7):1047-58.
5. Zong C, Gomes AV, Drews O, Li X, Young GW, Berhane B, Qiao X, French SW, Bardag-Gorce F, Ping P: Regulation of murine cardiac 20S proteasomes: role of associating partners. Circ Res. 2006 Aug; 99(4):372-80.

Methods that will be used:
Proteomics, Murine models of cardiac diseases, Genomics, Endpoint analysis using histology and physiology of the heart

College Scholarships Collaboration partners:
Prof. P Ping, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California at Los Angeles, USA

College Scholarships Profile of candidate‘s qualification:
The successful candidate should enjoy interactive teamwork in the field of cardiovascular biology and have a qualified MSc or equivalent degree in the life sciences, preferably biochemistry, cell biology, physiology, (human) biology, molecular biosciences or pharmacy. The candidate will have to perform in vivo experiments. Prior experience with animal models is an advantage. In-depth knowledge of modern methods in protein biochemistry or genetic manipulation in mice would be an advantage as well a good command of the English language.

College Scholarships PhD in University of Heidelberg University, Germany Information and Application detail in the url : http://www.w1system08.de/www.hbigs-heidelberg.de/intern/projectspub_project_for.php?a=030000169000000000000000000000030000000010000310128

College Scholarships PhD Application Closing Date: 30-09-2010

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